Nootropics: NA-Semax Amidate & NA-Selank Update

I’ve used both N-Acetyl Semax Amidate and N-Acetyl Selank since I first posted (January 2016, approximately 7 months).  I might have a few days off, in between uses, now and then.

Selank definitely has a mild sedating and anxiolytic effect.  I do not suffer with much anxiety in general during the day.  In some circumstances, like when I am out at a restaurant or grocery store alone, I get fairly intense feelings of social anxiety and negative self-concept.  I do not think that Selank has helped with this at all.  I think only a very strong drug could combat these feelings when I have them, as they are pervasive and strong within those contexts.

I wouldn’t recommend Selank as an intervention for that kind of anxiety.

It does, however, have a mild mood elevation and relaxation effect.  It also helps clear your head a bit.

N-Acetyl Semax Amidate is mildly stimulating.  It isn’t enough to keep you awake if you are tired.  It won’t prevent you from sleeping (or me, at least) if you need it.  It also clears your head a bit.

The effects of both supplements are what I would consider mild and slightly beneficial.

If you are looking for something that will drastically improve your cognition or help your mood, I don’t think either of these substances are for you.

If, however, you want to experience something that gives you a little boost, then these are for you.  I alway look forward to using them, but I don’t feel like I have to.  I guess it’s a bit like soda although not as addictive.  I don’t feel bad or needy when I don’t take Semax or Selank, although the idea of using them is usually welcome.

My dose is usually once or twice a day.  Sometimes I will take 600 mcg (two nasal insufflation doses of 300 mcg) of NA Semax Amidate in the morning and 400 mcg (two nasal insufflation doses of 200 mcg) of NA Selank in the evening.  Sometimes I will mix Semax and Selank in the day.  Sometimes one dose of each, sometimes two of each.

I guess I would describe Semax as being like a bit of coffee, not much, without any jitters or anxiety.  Just a little clarity.  My mind doesn’t race, become disconnected, or confused.  I am just a bit more alert, sharper, clear.  Or at least I have that feeling.

I have experienced no noticeable improvements in creativity, productivity, memory, word choice, or any such cognitive skills while on either.

I will continue to use both Semax and Selank, however, because they do make me feel good.  I cannot describe it.  There is no euphoria or anything like that, but they do make you feel a little better.  Like something little but noticeable.  Maybe someone smiles at you or you do a small task you’ve been procrastinating over.  It’s like that.  Not huge, but nice.

Both are mild and subtle.  I think that they are perfect for things like reading for enjoyment or maybe before taking a class.  I don’t think they are good for helping you push yourself or getting you to do some difficult task better or keeping you up to cram or finish a paper or something like that.

I think they are luxuries that may help you live a little better if you’re lucky enough to be able to afford their use.

 

N-Acetyl Semax Amidate and N-Acetyl Selank

I purchased N-Acetyl Semax Amidate and N-Acetyl Selank nasal sprays from Ceretropic around a month ago.  I’ve been using both daily.  Generally, I will use Semax in the day and Selank a few hours before bed.  The dose is 100 mcg per spray.

I have also been using a Noopept nasal spray.

The experience with both of these has been subtle.  I have tried using a variety of dose levels, ranging from 100 mcg of just one to 400 mcg of both.

The anxiolytic effects of Selank are noticeable even at low doses.  Before I got used to it, I decided this was definitely something I would only take near bed-time and not when I had a lot of stuff to do.  It made me tired and even a little drunk at first, but after a some days of use that effect wore off.

I am really at a loss to describe the effects of each.  Semax is definitely a little stimulating.  Selank is more relaxing.  In terms of mental clarity, memory, and other cognition-enhancing effects, I’d have to say that subtle is the key word.  There were no dramatic, noticeable increases.  I never went, “Holy fuck! I’m just ON today!”

I did find myself simply not experiencing the tip of the tongue phenomenon as much as well as being able to remember better.  But this is in retrospect and only because I can recall periods where I had a lack of the emotional reactions which unfortunately attend memory or word lapses on my account.  I feel embarrassed and stupid when it happens.  It is only in retrospect that I have realized, hey, I didn’t feel like that at all for the past day or so.

That is not to say days have gone by without incident, but I would say that the incidences are fewer.

In terms of clarity of thought, increased attention span, and ability to focus, again, I think the effects are very subtle.  They may well enhance these capacities, but not dramatically.

One thing I have noticed is a marked desire and anticipation for taking the doses.  They make me feel better for a while.  So, this leads me to believe that while every website I’ve looked at regarding the two claim that they are non-addictive, I believe that they are psychologically addictive.

I say this, because when I was running out, I got a little bit of an anxious, “Oh no! I want more of this stuff!” feeling.  That is certainly a sign of psychological addiction.

I’ve read that these drugs affect the activity of dopamine and serotonin, and I believe it.

I wish I could be more lucid regarding my experiences with these two substances.  I think what needs to happen is for me to take them alone many hours apart and take care to notice what is going on regarding them.  I may do this.

I re-ordered two more bottles, this time at the higher doses (300 mcg Semax and 200 mcg Selank).  I’ll dedicate a few days to taking them without Noopept or each other.  I’ll space out the doses, and then I’ll report my experiences here.

Would I recommend them?  Yes… if it’s true that they aren’t physically addictive.  I’ve been a few days off of them during this time span, and I did not experience any funk, negativity, unpleasant emotions, or physical symptoms as a result of not taking them.  So I doubt they are physically addictive.  But they are psychologically addictive, at least for me.

That being said, the reason I would recommend them is for that very factor.  They help you feel better, I think, on a daily basis.  I believe they have made me more emotionally even in general, and less reactive.  They also seem to mellow out some compulsive tendencies of mine.

As for the cognitive enhancing effects, they are mild but noticeable, if only in looking back and realizing that I had fewer embarrassing forgetful moments or those times when I mean to say one word and think I’m saying it, but another comes out of my mouth based on what I was just thinking about.

Noopept Experience

A long time ago I purchased some Noopept powder from Nootropics Depot.  As with most nootropics I’ve tried, I had an initial excitement about it, but then the love affair quickly tapered off.  My experiences with racetams have usually left me feeling a bit spacey and off. [Since posting I have learned that while Noopept is similar in structure to racetams, it is not part of the racetam family. -SM]

I decided to give it another go, but this time I changed the delivery method.  I took an old 1.5 oz saline nasal spray bottle and emptied it.  I thoroughly mixed about 200 mg of Noopept with distilled water and filled the spray bottle to 3/4ths with it.

For the past several days (I’d say about four), I have been using the spray bottle to take it through nasal insufflation.  At first I tried a spray in each nostril.  As the days progressed, I found I needed much less, and I only used it a few hours after I felt no noticeable effects from the Noopept.

What has happened?

My vision is noticeably clearer.  Colors are more vivid.  This effect has become long lasting in the past couple of days.  That is, I can notice it when I wake up.  Also, it is as if my myopia has become a little better.  I was amazed today to notice that I could see numbers some distance away more clearly.  It’s a two-phase thing.  The first phase is when the numbers are a bit blurry, but if I keep looking, suddenly they come into focus and I see them very clearly.  There is still a bit of a fuzzy aura around them.

I suspect that my eyes are just as bad as they were, but the Noopept is doing something to the visual parts in my brain.  It seems to be upping the signal.  What I think is happening is that my eyes are seeing the blurry number, but my brain recognizes what the number is and imposes what it should see upon what I am actually seeing.  That’s my hypothesis anyway.

I feel a little more… I don’t want to say clearheaded… I feel that my brain activity is a little more even, if that makes any sense.  I don’t necessarily feel or perceive any more clarity of thought.  My memory isn’t much better, I don’t think.  But I am lacking the sort of dreamy haziness that usually comes with racetams.  There is also a sort of feeling of disconnection racetams give me, like I am floating just a little bit away from reality or my normal way of thinking and perceiving.  I’ve found that distracting in the past.  It’s there, a bit, but it is not as distracting.

I think the ideal dose for me is actually lower than 10 mg per pop.

A side effect that I guess is normal with drugs that affect choline is that I feel a bit stiff and crampy in various muscles.  This makes sense because choline affects muscle tone.  I think I may need to reduce the dose even more, because over the days there has been a noticeable buildup.  It tapers off, however, hours after I have taken a dose.  But it seems to be building, so when it occurs, it’s worse than the earlier time.

If I can adjust the dose to manage the stiffness better, I think I may continue with taking Noopept for a while.  Supposedly the real benefits from nootropics come from long-term use.

Another thing that has happened (which may very well be the result of the Noopept) is that last night I had a very strange, incredibly meaningful and emotional dream.  These kinds of dreams are rare for me.  It was almost as if I had a spiritual teacher who was trying to teach me something about life itself.  It made sense, and I think I may have learned something on a deep level.  May have been a fluke, however.  We’ll just have to see.

I have just gotten N-Acetyl-Selank and N-Acetyl-Semax-Amidate nasal sprays.  I will be taking those, too, and will probably post on my experiences.

I’ve already taken a dose of each. My first thoughts are that the Selank kinda takes me out of it.  That is, I can really feel the anxiolytic effects of it.  It made me pretty sleepy and relaxed, and I didn’t want to do anything.  I didn’t get good sleep last night, however, and that might be part of it.  What will give a better impression is a dose taken after a good, full night of sleep and when I’ve become alert and engaged in a wakeful participation with the day.  If it pulls me down from that upswing, then I’ll know that the anxiolytic effect is too strong for me… perhaps taking it at night would be better in that case.

Semax seemed a bit uplifting.  The effects of the Semax may have been modified by the Selank.  I will have to take Semax alone and notice what happens.

I’m very excited.  As I’ve grown older, I’ve noticed more fog and muddle-headedness.  I think I used to be a lot sharper than I am now, and it’s depressing.  I also feel a lack of motivation and purpose.  I think that, perhaps, if these substances can help my brain heal and repair itself, I might be able to get some of that back.  It feels for the first time using these substances that it might be possible.

I think my mistake in the past was thinking that more is better.  I think a better approach with this stuff is to start small and very mild and let it build gradually over time.  With the muscle cramping I think that the smaller amount of Noopept I’m taking may well be too much.  I think I may dilute what I have in the spray bottle even more.

We’ll see.

Soylent 1.1 Unboxing

When there was a lot of buzz about Soylent, I eagerly watched just about every video I could about it.  I found the topic very interesting and exciting.

Here is a youtube video about it:

 

So, I decided to bite the bullet an order some.  My order was placed on May 9th, 2014.  It just came in today, 5 months later.  Feel free to watch the unboxing video.  Enjoy as you see me become increasingly confused and frustrated at the lack of an oil measuring implement or any information as to how much oil to add with a measure (provided) of the powder… (It’s 1.5 teaspoons, btw.)

What I didn’t realize by eyeballing it is that a packet of powder and bottle of oil is one full day’s worth of nutrition.  A packet contains 3 “meals,” which means 6 half-meals.  So, the included scoop is 1/6th of a packet of powder.  I didn’t understand what should have been immediately apparent, a packet is one full day of food which is divided into 3 meals.  Why they chose to have a scoop the size of a half of a meal and not include an equivalent measure for the oil is probably due to the fly by the seat of your pants nature of the organization.  A lot of things seem helter skelter with Soylent so far.

Anyway, here’s the video:

The box it came in looked a little gimpy.  There were several layers of packing tape over the top of the box, which shows concern about sealing the package properly but also demonstrates that they are running a kind of DIY shipping and don’t have their business streamlined there.

The packages inside, however, had some polish.  They were all sealed with a single, neat application of clear packing tape.  The boxes inside were unblemished and uncrumpled with no holes, marring, or damage to them.  I received a box with a pitcher and measuring cup and two boxes (I ordered the extra set of soylent) containing bottles of oil and packets of powder.

You get a card and a small pamphlet (images included below) with information and instructions.  However, the material contains no instructions as to how much oil is supposed to go with a serving of one cup of the powder.  Nor is there a measuring spoon for this amount.  From what I’ve read, Soylent really needs to get their shit together.  They’ve had problems with production and shipping as well as their formula causing people some intestinal distress and other symptoms.

I can understand some problems, but getting so much money from the kickstarter and having an engineer running the company… I have to think… wow.  I figured an engineer would research and design the business better at the outset.  But, then, maybe starting and running a big business is hard.  I can’t help but think, though, that some mismanagement has been involved.  I hope they iron out their problems.

Anyway, the missing instructions I was looking for regarding the amount of oil per scoop of powder can be found on their website, here.

They should print that out and include it with every package they ship.  Seriously.  Or just include a slip of paper printed with a url where you can download the latest edition of the manual.  It isn’t rocket science.

So, without further adieu, let’s look at some unboxing pics!

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This is a pic of the box it came in with several items removed from their containers.  The long skinny box on the left contained the pitcher and metallic scoop.  It also contained a small card which can be seen above the pitcher, as well as a little black card with white letters which says “soylent” in the logo font.  I guess this was supposed to be a magnet, but shit happens.

You can see the bottles of oil at the top and the manual to the right.  There were 7 bottles of oil, I removed one.  The two big white boxes contain bottles of oil and packets of powder.

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Side of the large box containing the powder and oil.

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Powder packet and oil bottle front.

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Powder packet and oil bottle back.

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Pitcher and scoop. The top of the pitcher looks to be water-tight when screwed in completely.

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Here is the little black card which, in a more perfect world, was probably supposed to be a refrigerator magnet, and below is a card that was also placed with the pitcher.

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This is the back side of the card.

Here are scans from the Soylent 1.1 manual:

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That’s all for now.  Stay tuned for mixing it, and then, later, drinking it and my opinions on the texture, taste, and how I feel an hour after.

 

 

 

 

Aquaponics Update

This is a video of my aquaponics setup.  In the video I state that I don’t need many fish, which is in error.  Reading about it, it turns out that I will probably need more.

Two goldfish have died so far.  The guppies, however, have all survived, and today most of the fish look spry, and they are eating.

I expect a shock to their systems when I add the clay medium, which I will have to rinse with tap-water to clear them from debris and clay dust.  That as well as the changes to the water created by the clay might change the water quality in a manner harmful to the fish. We’ll have to see.  I will add dechlorinator to the water as it circulates around the clay pebbles for the first time. Hopefully that will neutralize the bad stuff in the tap water.

I’ll post either a video or pics (or maybe a combo) when I put the clay in.

The timer is working properly.  The water flows when it is supposed to and stops when it is supposed to.  As I said in the previous blog entry, the reviewer on Amazon who said that the timers are bunk and never start properly apparently never reset the timer before plugging it in for the first time and programming it.  If I put up LED lights to support plant growth (I’ve looked and found one that seems right, fairly inexpensive and right for the size of my setup), I’m going to get another timer (same model) for the lights.

Python and Selenium

The School Information System (an application which manages a database which contains relevant information about faculty, staff, and students which also helps with communications, grade-book management, and other kinds of functions) we use handles new user passwords in a really shitty fashion. It gives each new user the same default password.

You can’t change this password through any kind of batch or global process, but you can, as admin, go to each user in the web interface and click a “Reset Password” button.

I didn’t see much of a problem with parents, because which parents are going to know that other parents are going to have the same password?

Students, however, are another issue altogether. I can totally see two students confiding in one another and discovering that their passwords are the same. I can also imagine them putting two-and-two together and attempting to log in as other students, setting their own passwords, and performing all kinds of shenanigans.

I decided we could get a staff member or two together and handle the issue by each tackling a grade per day in a process of cutting and pasting from an excel spreadsheet I made for usernames and passwords for students.

We started doing it, and I thought, oh no… there must be a better way. So I looked online and found some software which would help automate the process. It was fully functional for a trial period of 30 days. So, it worked.

But afterwards I was thinking, wait a minute… I used to program. There has to be a way to do this programmatically that isn’t too difficult.

I did a lot of googling and found various entries in stackexchange that I found more or less helpful. I looked at python and mechanize. I saw suggestions about using urllib and urllib2.

But then I found a gem: selenium.

Python and selenium are awesome. Selenium hijacks a browser of your choice and can get information via a very large number of query functions. It can also send clicks and keystrokes to various buttons, fields, etc. in the web-browser.

So, setting up a test program which would log in to the website and log out was a snap. It took me around a minute to inspect objects and write the functions for them.

I have yet to add functions to read in a csv file and loop logging in, changing passwords, and logging out, but that part is trivial.

I have to say, though, that if I need to do any repetitive form-filling processes over the web in the future, I have a simple means by which to do so.

Here is the code for those who may be curious, to find out how simple it is:

import time

from selenium import webdriver
from selenium.webdriver.common.keys import Keys

driver = webdriver.Firefox()
driver.get("https://www.website.com")
elem = driver.find_element_by_name("UserName")
elem.send_keys("jdoe@thisistheusername.net")
elem2 = driver.find_element_by_name("Password")
elem2.send_keys("jdoepassword123")
elem2.send_keys(Keys.RETURN)
time.sleep(5)
driver.get("https://www.website.com/logoffurl")

driver.close()

Package Delivery Blues

A delivery company, whose name I shall not express (ahem), has some lazy, lying, sack-of-shit employees for delivery staff on my route.

This delivery service doesn’t deliver. The drivers have placed packages at wrong addresses and claimed they could not gain entry into my complex (which is total bullshit) or to be otherwise unable to deliver to my address (also bullshit). Other delivery services encounter no such problems.

Many times I’ve had to intervene to get in my hands on a package from them.

After a while of this, I became proactive. Whenever I saw through tracking information that this company was involved, I’d call them and have them hold the package at a company facility to which I would drive. I’ve had good luck with that. I think it is because the carrier has to have more accountability when she brings the package to a pickup location (another employee has to receive it). When delivering to a customer, “leaving the package at the door,” they could scan it and toss it wherever.

I wonder if their scanners tag confirmations with GPS data. It would help ensure against abuse by a driver who was being lazy.

A recent order “delivered” by this company, once again, registered as delivered to my front door when no package is in sight. Hopefully it got delivered to an honest neighbor and will find its way to me soon.

 

Nootropics – Sunifiram Experiences

General Information about Sunifiram

Sunifiram is a cognition-enhancing drug that is available over the counter.  It is one of the “newer” nootropics (drugs used to enhance memory or cognitive functions).  According to wikipedia:

Sunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam.”

Also according to wikipedia, it has the following mechanisms of action:

  • Sunifiram activates AMPA-mediated neurotransmission.
  • It enhances LTP in a bell-shaped dose–response relationship. This enhancement by sunifiram is associated with an increase in phosphorylation of AMPAR through activation of protein kinase II (CaMKII) and an increase in phosphorylation of NMDAR through activation of protein kinase C α (PKCα). More specifically, sunifiram stimulates the glycine-binding site of NMDAR with concomitant PKCα activation through Src kinase. Enhancement of PKCα activity triggers hippocampal LTP through CaMKII activation.
  • Sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation. PKC activation may be a common mechanism amongst cognition stimulating drugs from different chemical classes.
  • Sunifiram aids in the release of acetylcholine in the cerebral cortex.

Typical dosage is between 4 and 11 milligrams per 150 lbs.

You can find detailed information about the drug at http://examine.com/supplements/Sunifiram/

Most importantly, the safety information found on examine.com about sunifiram states: “A study noting efficacy of sunifiram (0.001mg/kg denoted minimum effective dose) failed to find any overt toxic symptoms with a 1000-fold higher dose injected (1mg/kg).”

First Experience

Summary

I have heard people describe LSD (at a low dosage) as a drug that increases awareness.  Colors become more vivd.  You see more clearly.  Sounds have greater depth and clarity.  The world becomes more alive and fascinating.  It seems as if the filters that prevent sensory information from reaching the brain are somehow disabled or changed in a manner that lets more information through.  The downside of this is sensory overload.  Sunifiram had a similar kind of effect on me, however the world did not become entrancing, and there were no sensory distortions.  I was never out of it, fixated by something, or hallucinating. To the contrary, I found my overall attention and sobriety increased.  My visual and audio acuity increased.  I experienced more of what was around me.

I found things, at times, to be a little overwhelming and experienced some anxiety.  What I found most challenging were shifts in my attention caused by changes in my environment.  The attention shifted easily, but the influx of new information at a greater intensity than normal was somewhat jarring and made me anxious.  I simply was not used to it.  I had no problem controlling my attention, but whatever I attended to came in more fully, providing more information about the world around me than usual.  This taxed my mind/body and produced anxiety.  I believe this is something I can adapt to and is probably related to the strength of the dose I took (which was close to the recommended dose for my body weight).

Caveat

I am a little skeptical about my first experiences with substances because I am well aware of the placebo effect and how suggestible I can be at times.

That said, I will just give an account of my experiences as they occurred without speculating too much as to whether they were the products of sunifiram or not.  Details from subsequent experiences should create a more accurate picture.

Experience

I was very excited when the nootropics arrived (I ordered noopept, phenylpiracetam, and sunifiram), and I wanted to try sunifiram first.  It is considered a non-piracetam type drug, and I have tried various kinds of “racetams.”  I was eager for a new experience.

I was shocked to see just how little a pile of 7 milligrams of powder looks.  My scale is accurate to ~3 milligrams, so I was unsure as to exactly how much I was getting.  The amount, however, was very tiny.  It could easily fit on the tip of my pinky without falling off.

I may have taken anywhere between 4 and 10 milligrams.  I am around 160 lbs.

I wet my finger and rubbed the powder off of the small, metal weighing dish, and then rubbed along the inside of my mouth underneath my tongue to saturate the tissues with it.

I think I could start to feel the effects within 5 to 10 minutes.  It started to peak at around 15-20 minutes.

It increases awareness and stimulates.  I became very, very aware of myself and my surroundings, mostly of sounds.  They were very clear.  When I locked the door to my apartment, the sound of my keys clinking together was exceptionally clear, almost hypnotic.  I was amazed at the clarity. I experienced a heightened awareness of the ambient sounds of my apartment complex as I walked through the halls.

My visual field was slightly different than usual.  I cannot quite say how.  At times it was almost as if I had tunnel vision, but not really.  I was just very focused on whatever caught my attention, but not necessarily to the exclusion of other things, not like being transfixed.  Just very attentive.

I did not notice more efficiency in thinking or improvements in memory.  The increase of sensory awareness regarding sound and vision was very distracting.  It’s not like I couldn’t contemplate.  I just didn’t want to.  I was too involved in the world around me.

I did not experience changes in body heat or increased sweating as some individuals reported on reddit.

I played a game of pathfinder with friends, and I found it a little strange.  There was a new person, and I am sometimes nervous around new people, unless there is something about the person that is very comforting or disarming. Perhaps the sunifiram was agitating social anxiety.  I cannot comment upon that accurately.  I can only speculate.  It was my only social experience while on it.

The drug created a kind of schism between my normal sense of self and what was going on in the world around me.  I could experience my surroundings acutely, but not necessarily process the information adequately.  I suppose I could liken it to when I was learning saber fencing.  When I got comfortable, the instructor would increase the speed and complexity of things, and this would not allow me to think or orient myself.  I had to react.

Sunifiram seemed to be increasing my overall sensory awareness, and the increased input was just too much to handle in my normal mode of being.

It put me off-balance in a number of ways. Socially, I handled it by being somewhat reserved and focusing mostly on the interactions which made me feel most comfortable.  There are a few very friendly, humorous people in our gaming group, and I tried to focus as much as I could on interacting with them and ignoring what I didn’t like.

After an hour or two of gaming, the new member started lightening up, smiling, and being more participatory.  She also smiled at me a few times and laughed at a few thing I said (intending to be funny).  As she started to unwind, so did I.

I normally would not feel as much social anxiety when meeting a new person in a similar scenario.  I think having a new person in our group along with a heightened level of sensory sensitivity created a feeling of imbalance and overwhelm which resulted in anxiety.

I listened to some music while driving as I decided the effect of the drug would not impair my driving ability.  The experience of the music was akin to what some people have described under the effects of marijuana, but not entrancing.  The increased musical awareness was not distracting or irritating, rather, it was pleasant.  I had no desire to turn the music off, and when driving needed my absolute full attention, I was completely unaware of the music, as is normal for me when driving.  I could tell that if I were in another situation, I could really relax and enjoy the music more fully than usual.  I would like to spend some comfortable time alone listening to music while under the effects of sunifiram.  I think that would be very enjoyable.  It may also assist in language acquisition in that you may hear inflections and other vocal variations better, so I may try it while listening to a pimsleur recording.

I noticed that I was very aware of the situations on the highway and the various vehicles around me.  I became somewhat anxious, as I began to worry that the drug might affect my attention in some kind of dangerous way, putting other drivers and me at risk.  In the end, there was nothing to worry about.  I probably drove better than usual, as I was more aware.  Again, I did not find myself attending to one thing at the expense of other important sensory input, such as focusing on one car while unconsciously and dangerously filtering out what is going on with other cars around me as in a trance-like or super-focused way.  I did, however, find, at times, the experience of shifting attention from one thing to another as is necessary when driving to have a kind of jarring effect.  Not super bad, but disconcerting.  This was when I started to worry that the drug might impair my driving ability.  It is hard to describe.  It wasn’t as though it was hard to move from one thing to another, to be brought from one thing to another.  That was easy.  What was hard was the intensity of the new incoming information.  When I needed to be aware of something, such as a car moving into an adjacent lane or something like that, I was *very* aware of it when it happened, and then, once I saw the car had moved in to the adjacent lane, I was *very* aware of the road in front of me and where I needed to go.  I think the attentional shifts were creating some anxiety.

Thoughts

In retrospect, I think that what is going on with the anxiety I experienced was a matter of familiarity and adaptation.  I normally have a bit of brain fog, there are certain things that remain dull and certain things that are clear and in focus.  What happened was the sunifiram suddenly brought a hell of a lot more into clarity and focus and my brain was just like, WTF?  What am I going to do with all this information?  My attention, I think, was being over-taxed.

When I try another dose, I will either take less or take the same amount but choose to remain indoors in an environment with stable, controlled input.  Not something as dynamic as driving or socially interacting with a group and an unfamiliar person.

Recommendations

Right now I cannot say with confidence that I could recommend or advise against the use of sunifiram.  I do not have enough experiences with it.

What I can say is that it is a powerful substance and that you should be careful regarding the dosage and setting when first taking it.  I had some anxiety in my experience.  I could imagine what it could have been like had I taken too large of a dose or had been in a very stressful situation.  It could have been a nightmare.

I can see the benefits of using it to enhance various aesthetic experiences.  I can say with some certainty that watching nature, going to an art museum, listening to music, etc., would be enhanced by sunifiram.

I imagine that it may help a person remain aware and sharp when fatigued.  However, since I have not used it when mentally or physically fatigued, I cannot recommend its use in that scenario.  Will it make you feel mentally refreshed?  Or will you feel like an exhausted horse being relentlessly whipped?  Some stimulants taken during exhaustion can have that effect.

I also imagine that it may be helpful for study or problem solving, but, again, I will need to test it in those activities before I can make a useful comment in that regard.

Second Sunifiram Experience

Dose: 5 milligrams or less

I made sure to decrease the dose, and I also took some phosphatidylcholine, which is generally recommended when taking nootropics.  Many nootropics increase or otherwise affect acetylcholine in the brain. The theory is that more choline is used up when you take nootropics that increase acetylcholine levels.  Some negative effects from nootropics (such as crashes after using them) are attributed to not taking a choline supplement.

Experience

I could feel the stimulant effect, but not as heavily as before.  I experienced a slight increase in ease of concentration during mental tasks during my work day. The concentration felt very satisfying.  I felt as if I could apply myself just that little bit more fully to what I was doing.  This could, however, be due to the placebo effect.

Because I had a poor night’s sleep before, I had a lingering feeling of tiredness and also some general mental fog.  The sunifiram did not cut through that, and may have somehow contributed to it. I’m not sure.

I experienced a strange sensation of separateness like before but not as pronounced.  I just felt vaguely not there, as if some part of me was separated from my experience, adrift. I could, however, easily attend to what was going on around me, what people were saying, and the like.  I think that my experimentation with stimulating nootropics is affecting sleep.  It took me a while to get into deep sleep last night, and I did a lot of tossing and turning.

At the end of my work day I felt tired, but a little stimulated.  When I got home, I did not feel the need to take a nap or otherwise crash, but I did feel somewhat exhausted.

I experienced an increased enjoyment of music again, but this time it was not as pronounced as before.

Thoughts

I think today’s experience was a bit lackluster.  I want to find out just what exactly this stuff is good for.  I am already convinced that it is generally stimulating and does certainly affect attention and focus.  I am uncertain about the cons it might have in terms of affecting sleep and also possibly creating a crash.  More time and experience with it will yield more information.

I suspect that taking it on a day in which I am relaxed, have eaten well, am well rested, and am able to comfortably engage in a variety of tasks with no feeling of hurry or rush will show me most clearly what I want to know.

I plan to use it and read some fiction, listen to some music, meditate, write, and get some thinking done, all in a relaxed way.  It may be best to record my experiences right after they have occurred, wait a while, and the reflect and comment upon them later.