General Information about Sunifiram<\/b><\/p>\n
Sunifiram<\/b> is a cognition-enhancing drug that is available over the counter.\u00a0 It is one of the \u201cnewer\u201d nootropics<\/a> (drugs used to enhance memory or cognitive functions).\u00a0 According to wikipedia<\/a>:<\/p>\n \u201cSunifiram (DM-235)<\/b> is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam<\/a>.\u201d<\/p>\n Also according to wikipedia, it has the following mechanisms of action:<\/p>\n Typical dosage is between 4 and 11 milligrams per 150 lbs.<\/p>\n You can find detailed information about the drug at http:\/\/examine.com\/supplements\/Sunifiram\/<\/a><\/p>\n Most importantly, the safety information found on examine.com<\/a> about sunifiram states: \u201cA study noting efficacy of sunifiram (0.001mg\/kg denoted minimum effective dose) failed to find any overt toxic symptoms with a 1000-fold higher dose injected (1mg\/kg).\u201d<\/p>\n First Experience<\/b><\/p>\n Summary<\/b><\/p>\n I have heard people describe LSD (at a low dosage) as a drug that increases awareness.\u00a0 Colors become more vivd.\u00a0 You see more clearly.\u00a0 Sounds have greater depth and clarity.\u00a0 The world becomes more alive and fascinating.\u00a0 It seems as if the filters that prevent sensory information from reaching the brain are somehow disabled or changed in a manner that lets more information through.\u00a0 The downside of this is sensory overload.\u00a0 Sunifiram had a similar kind of effect on me, however the world did not become entrancing, and there were no sensory distortions.\u00a0 I was never out of it, fixated by something, or hallucinating. To the contrary, I found my overall attention and sobriety increased.\u00a0 My visual and audio acuity increased.\u00a0 I experienced more of what was around me.<\/p>\n I found things, at times, to be a little overwhelming and experienced some anxiety.\u00a0 What I found most challenging were shifts in my attention caused by changes in my environment.\u00a0 The attention shifted easily, but the influx of new information at a greater intensity than normal was somewhat jarring and made me anxious.\u00a0 I simply was not used to it.\u00a0 I had no problem controlling my attention, but whatever I attended to came in more fully, providing more information about the world around me than usual.\u00a0 This taxed my mind\/body and produced anxiety.\u00a0 I believe this is something I can adapt to and is probably related to the strength of the dose I took (which was close to the recommended dose for my body weight).<\/p>\n Caveat<\/b><\/p>\n I am a little skeptical about my first experiences with substances because I am well aware of the placebo effect and how suggestible I can be at times.<\/p>\n That said, I will just give an account of my experiences as they occurred without speculating too much as to whether they were the products of sunifiram or not.\u00a0 Details from subsequent experiences should create a more accurate picture.<\/p>\n Experience<\/b><\/p>\n I was very excited when the nootropics arrived (I ordered noopept, phenylpiracetam, and sunifiram), and I wanted to try sunifiram first.\u00a0 It is considered a non-piracetam type drug, and I have tried various kinds of \u201cracetams.\u201d\u00a0 I was eager for a new experience.<\/p>\n I was shocked to see just how little a pile of 7 milligrams of powder looks.\u00a0 My scale is accurate to ~3 milligrams, so I was unsure as to exactly how much I was getting.\u00a0 The amount, however, was very tiny.\u00a0 It could easily fit on the tip of my pinky without falling off.<\/p>\n I may have taken anywhere between 4 and 10 milligrams.\u00a0 I am around 160 lbs.<\/p>\n I wet my finger and rubbed the powder off of the small, metal weighing dish, and then rubbed along the inside of my mouth underneath my tongue to saturate the tissues with it.<\/p>\n I think I could start to feel the effects within 5 to 10 minutes.\u00a0 It started to peak at around 15-20 minutes.<\/p>\n It increases awareness and stimulates.\u00a0 I became very, very aware of myself and my surroundings, mostly of sounds.\u00a0 They were very clear.\u00a0 When I locked the door to my apartment, the sound of my keys clinking together was exceptionally clear, almost hypnotic.\u00a0 I was amazed at the clarity. I experienced a heightened awareness of the ambient sounds of my apartment complex as I walked through the halls.<\/p>\n My visual field was slightly different than usual.\u00a0 I cannot quite say how.\u00a0 At times it was almost as if I had tunnel vision, but not really.\u00a0 I was just very focused on whatever caught my attention, but not necessarily to the exclusion of other things, not like being transfixed.\u00a0 Just very attentive.<\/p>\n I did not notice more efficiency in thinking or improvements in memory.\u00a0 The increase of sensory awareness regarding sound and vision was very distracting.\u00a0 It\u2019s not like I couldn\u2019t contemplate.\u00a0 I just didn\u2019t want to.\u00a0 I was too involved in the world around me.<\/p>\n I did not experience changes in body heat or increased sweating as some individuals reported on reddit<\/a>.<\/p>\n I played a game of pathfinder with friends, and I found it a little strange.\u00a0 There was a new person, and I am sometimes nervous around new people, unless there is something about the person that is very comforting or disarming. Perhaps the sunifiram was agitating social anxiety.\u00a0 I cannot comment upon that accurately.\u00a0 I can only speculate.\u00a0 It was my only social experience while on it.<\/p>\n The drug created a kind of schism between my normal sense of self and what was going on in the world around me.\u00a0 I could experience my surroundings acutely, but not necessarily process the information adequately.\u00a0 I suppose I could liken it to when I was learning saber fencing.\u00a0 When I got comfortable, the instructor would increase the speed and complexity of things, and this would not allow me to think or orient myself.\u00a0 I had to react.<\/p>\n Sunifiram seemed to be increasing my overall sensory awareness, and the increased input was just too much to handle in my normal mode of being.<\/p>\n It put me off-balance in a number of ways. Socially, I handled it by being somewhat reserved and focusing mostly on the interactions which made me feel most comfortable.\u00a0 There are a few very friendly, humorous people in our gaming group, and I tried to focus as much as I could on interacting with them and ignoring what I didn\u2019t like.<\/p>\n After an hour or two of gaming, the new member started lightening up, smiling, and being more participatory.\u00a0 She also smiled at me a few times and laughed at a few thing I said (intending to be funny).\u00a0 As she started to unwind, so did I.<\/p>\n I normally would not feel as much social anxiety when meeting a new person in a similar scenario.\u00a0 I think having a new person in our group along with a heightened level of sensory sensitivity created a feeling of imbalance and overwhelm which resulted in anxiety.<\/p>\n I listened to some music while driving as I decided the effect of the drug would not impair my driving ability.\u00a0 The experience of the music was akin to what some people have described under the effects of marijuana, but not entrancing.\u00a0 The increased musical awareness was not distracting or irritating, rather, it was pleasant.\u00a0 I had no desire to turn the music off, and when driving needed my absolute full attention, I was completely unaware of the music, as is normal for me when driving.\u00a0 I could tell that if I were in another situation, I could really relax and enjoy the music more fully than usual.\u00a0 I would like to spend some comfortable time alone listening to music while under the effects of sunifiram.\u00a0 I think that would be very enjoyable.\u00a0 It may also assist in language acquisition in that you may hear inflections and other vocal variations better, so I may try it while listening to a pimsleur recording.<\/p>\n I noticed that I was very aware of the situations on the highway and the various vehicles around me.\u00a0 I became somewhat anxious, as I began to worry that the drug might affect my attention in some kind of dangerous way, putting other drivers and me at risk.\u00a0 In the end, there was nothing to worry about.\u00a0 I probably drove better than usual, as I was more aware.\u00a0 Again, I did not find myself attending to one thing at the expense of other important sensory input, such as focusing on one car while unconsciously and dangerously filtering out what is going on with other cars around me as in a trance-like or super-focused way.\u00a0 I did, however, find, at times, the experience of shifting attention from one thing to another as is necessary when driving to have a kind of jarring effect.\u00a0 Not super bad, but disconcerting.\u00a0 This was when I started to worry that the drug might impair my driving ability.\u00a0 It is hard to describe.\u00a0 It wasn\u2019t as though it was hard to move from one thing to another, to be brought from one thing to another.\u00a0 That was easy.\u00a0 What was hard was the intensity of the new incoming information.\u00a0 When I needed to be aware of something, such as a car moving into an adjacent lane or something like that, I was *very* aware of it when it happened, and then, once I saw the car had moved in to the adjacent lane, I was *very* aware of the road in front of me and where I needed to go.\u00a0 I think the attentional shifts were creating some anxiety.<\/p>\n Thoughts<\/b><\/p>\n In retrospect, I think that what is going on with the anxiety I experienced was a matter of familiarity and adaptation.\u00a0 I normally have a bit of brain fog, there are certain things that remain dull and certain things that are clear and in focus.\u00a0 What happened was the sunifiram suddenly brought a hell of a lot more into clarity and focus and my brain was just like, WTF?\u00a0 What am I going to do with all this information?\u00a0 My attention, I think, was being over-taxed.<\/p>\n When I try another dose, I will either take less or take the same amount but choose to remain indoors in an environment with stable, controlled input.\u00a0 Not something as dynamic as driving or socially interacting with a group and an unfamiliar person.<\/p>\n Recommendations<\/b><\/p>\n Right now I cannot say with confidence that I could recommend or advise against the use of sunifiram.\u00a0 I do not have enough experiences with it.<\/p>\n What I can say is that it is a powerful substance and that you should be careful regarding the dosage and setting when first taking it.\u00a0 I had some anxiety in my experience.\u00a0 I could imagine what it could have been like had I taken too large of a dose or had been in a very stressful situation.\u00a0 It could have been a nightmare.<\/p>\n I can see the benefits of using it to enhance various aesthetic experiences.\u00a0 I can say with some certainty that watching nature, going to an art museum, listening to music, etc., would be enhanced by sunifiram.<\/p>\n I imagine that it may help a person remain aware and sharp when fatigued.\u00a0 However, since I have not used it when mentally or physically fatigued, I cannot recommend its use in that scenario.\u00a0 Will it make you feel mentally refreshed?\u00a0 Or will you feel like an exhausted horse being relentlessly whipped?\u00a0 Some stimulants taken during exhaustion can have that effect.<\/p>\n I also imagine that it may be helpful for study or problem solving, but, again, I will need to test it in those activities before I can make a useful comment in that regard.<\/p>\n Second Sunifiram Experience<\/b><\/p>\n Dose: 5 milligrams or less<\/p>\n I made sure to decrease the dose, and I also took some phosphatidylcholine<\/a>, which is generally recommended when taking nootropics.\u00a0 Many nootropics increase or otherwise affect acetylcholine<\/a> in the brain. The theory is that more choline is used up when you take nootropics that increase acetylcholine levels.\u00a0 Some negative effects from nootropics (such as crashes after using them) are attributed to not taking a choline supplement.<\/p>\n Experience<\/b><\/p>\n I could feel the stimulant effect, but not as heavily as before.\u00a0 I experienced a slight increase in ease of concentration during mental tasks during my work day. The concentration felt very satisfying.\u00a0 I felt as if I could apply myself just that little bit more fully to what I was doing.\u00a0 This could, however, be due to the placebo effect.<\/p>\n Because I had a poor night\u2019s sleep before, I had a lingering feeling of tiredness and also some general mental fog.\u00a0 The sunifiram did not cut through that, and may have somehow contributed to it. I\u2019m not sure.<\/p>\n I experienced a strange sensation of separateness like before but not as pronounced.\u00a0 I just felt vaguely not there, as if some part of me was separated from my experience, adrift. I could, however, easily attend to what was going on around me, what people were saying, and the like.\u00a0 I think that my experimentation with stimulating nootropics is affecting sleep.\u00a0 It took me a while to get into deep sleep last night, and I did a lot of tossing and turning.<\/p>\n At the end of my work day I felt tired, but a little stimulated.\u00a0 When I got home, I did not feel the need to take a nap or otherwise crash, but I did feel somewhat exhausted.<\/p>\n I experienced an increased enjoyment of music again, but this time it was not as pronounced as before.<\/p>\n Thoughts<\/b><\/p>\n I think today\u2019s experience was a bit lackluster.\u00a0 I want to find out just what exactly this stuff is good for.\u00a0 I am already convinced that it is generally stimulating and does certainly affect attention and focus.\u00a0 I am uncertain about the cons it might have in terms of affecting sleep and also possibly creating a crash.\u00a0 More time and experience with it will yield more information.<\/p>\n I suspect that taking it on a day in which I am relaxed, have eaten well, am well rested, and am able to comfortably engage in a variety of tasks with no feeling of hurry or rush will show me most clearly what I want to know.<\/p>\n I plan to use it and read some fiction, listen to some music, meditate, write, and get some thinking done, all in a relaxed way.\u00a0 It may be best to record my experiences right after they have occurred, wait a while, and the reflect and comment upon them later.<\/p>\n","protected":false},"excerpt":{"rendered":" General Information about Sunifiram Sunifiram is a cognition-enhancing drug that is available over the counter.\u00a0 It is one of the \u201cnewer\u201d nootropics (drugs used to enhance memory or cognitive functions).\u00a0 According to wikipedia: \u201cSunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam.\u201d Also […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[3,4],"tags":[36,35,39,38,37,33,34],"class_list":["post-38","post","type-post","status-publish","format-standard","hentry","category-commentary","category-review","tag-brain","tag-cognitive-enhancer","tag-improvement","tag-memory","tag-mind","tag-nootropics","tag-sunifiram"],"yoast_head":"\n\n